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The Skin
What is Cancer?
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Medical Terms
Actinic keratosis (ak-TIN-ik ker-a-TO-sis): A precancerous condition of thick and scaly patches of skin; also called solar or senile keratosis.

Anesthetic (an-es-THET-ik): a drug that causes loss of sensation or feeling in a part (local) or all (general) of the body.

Basal cell carcinoma (BAY-sal sel kar-si-NO-ma): A type of skin cancer in which the cancer cells resemble the basil cells of the epidermis.

Basal cells: Small, round cells found in the lower part, or base, of of the epidermis.

Benign (be-NINE): Not cancerous, does not invade nearby tissue or spread to other parts of the body.

Biopsy (BY-op-see): The removal of a sample of tissue that is then examined under a microscope to check for cancer cells.

Cancer: A general term for the more than 100 diseases in which cells grow and divide abnormally. Cancer cells can spread through the blood or lymphatic system to other parts of the body.

Carcinogen (kar-SIN-o-jin): Any agent that is known to cause cancer.

Carcinoma (kar-si-NO-ma): A type of cancer that begins in the lining or covering tissues of an organ.

Clinical Trials: Studies conducted with people. Each study is designed to answer scientific questions and to find better ways to prevent or treat cancer.

Cryosurgery (kry-o-SIR-je-ree): Destruction of tissue by applying extreme cold.

Curettage (kyoo-re-TAZH): Removal of tissue with a curette.

Curette (kyoo-RET): A spoon-shaped instrument with a sharp edge.

Dermatologist (der-ma-TOL-o-jist): A doctor who specializes in the diagnosis and treatment of skin diseases.

Dermis (DER-mis): The lower layer of skin.

Electrodesiccation (e-LEK-tro-des-i-KAY-shun): Use of an electric current to destroy cancerous tissue and control bleeding.

Epidermis (epi-DER-mis): The surface layer of skin.

Fluorouracil (floo-ro-YOOR-a-sil): An anticancer drug. Its chemical name is 5-fluorouracil, commonly called 5-FU.

Follicles (FAHL-i-kuls): Shafts through which hair grows.

Interferon (in-ter-FEER-on): A substance that can improve the body's natural response to the presence of cancer. It slows the rate of growth and division of cancer cells, causing them to become sluggish and die.

Kaposi's sarcoma (KAP-o-seez sar-KO-ma): A relatively rare type of cancer that develops on the skin of some elderly persons or those with a weak immune system, including those with acquired immune deficiency syndrome (AIDS).

Lymph (limf): The almost colorless fluid that travels through the lymphatic system and carries cells that help fight infection and disease.

Lymph nodes: Small, bean-shaped structures in the lymphatic system. The lymph nodes store special cells that can trap cancer cells or bacteria traveling through the body in lymph.

Lymphatic System (lim-FAT-ik): The tissue and organs that produce, carry, and store cells that can fight infection and disease. This system includes the bone marrow, spleen, thymus, lymph vessels, and lymph nodes.

Malignant (ma-LIG-nant): Cancerous (see Cancer).

Melanin (Mel-a-nin): The pigment of the skin. The amount of this substance accounts for variations in skin color in different people and different races.

Melanocytes (me-LAN-o-sites): Cells that form and contain a pigment called melanin.

Melanoma (mel-a-NO-ma): Cancer that begins in the melanocytes. Melanoma usually starts in the skin, often in a dark mole. Unlike the more common skin cancers, melanoma tends to spread to internal organs.

Metastasize (me-TAS-ta-size): To spread from one part of the body to another. When cancer cells metastasize and form secondary tumors, the cells in the metastatic tumor are like those in the original (primary) tumor.

Mycosis fungoids (my-KO-sis fun-GOY-deez): a cancer of the body's immune, or defense system. This cancer, also called T-cell lymphoma , first appears on the skin.

Nonmelanoma skin cancer: Skin cancer that does not involve melanocytes. Basal cell cancer and squamous cell cancer are nonmelanoma skin cancers

Pathologist (pa-THOL-o-jist): A doctor who studies tissues removed from the body, then makes a diagnosis based on changes that diseases cause in these cells.

Photodynamic therapy (FO-to-die-NAM-ik): Treatment that destroys cancer calls with lasers and drugs that become active when exposed to light.

Plastic surgeon: A surgeon who specializes in minimizing scarring or disfigurement that may occur as a result of disease (such as skin cancer), accidents, or birth defects.

Precancerous (pre-KAN-ser-us): A term used to describe a condition that may or is likely to become cancer.

Prognosis(prog-NO-sis): The probable outcome of a disease, the prospect of recovery.

Radiation therapy (ray-dee-AY-shun): The use of high-energy rays to treat disease. Sources of radiation include x-ray, cobalt, and radium.

Risk factor: A substance or condition that increases an individual's chances of getting particular type of cancer.

Sebum (SEE-bum): An oily substance produced by the skin.

Skin Graft: Skin that is moved from one part of the body to another.

Squamous cell carcinoma (SKWAY-mus sel kar-si-NO-ma): A type of skin cancer in which the cancer cells resemble the squamous cells of the epidermis.

Squamous cells: Flat cells that look like fish scales and make up most of the epidermis.

Stage: The extent of disease.

Sun protection factor(SPF): A number on a scale (from 2 upward) for rating sunscreens. Sunscreens with an SPF of 15 to 30 protect the skin from most of the suns rays.

Sunscreen: A substance that blocks the effect of the sun's rays. Using lotions that contain sunscreens can reduce the risk of skin cancer.

Surgery: An Operation.

T-cell lymphoma (lim-FO-ma): A cancer of the immune system that appears in the skin; also called mycosis fungoides.

Topical chemotherapy (kee-mo-THER-a-pee): Treatment with anticancer drugs in a lotion or cream.

Tumor: An abnormal mass of tissue that results from excess cell division. Tumors perform no useful body function. They may be either benign or malignant.

Ultraviolate (UV) radiation (ul-tra-VI-o-let ray-dee-AY-shun): Invisible rays that are part of the energy that comes from the sun. UV radiation can burn the skin and can cause skin cancer. UV radiation that reaches the earth's surface is made up of two types of rays, called UVA and UVB rays. UVB rays are more likely than UVA rays sunburn, but UVA rays pass further into the skin. Scientists long thought that UVB radiation can cause skin cancer. They now think that UVA radiation also may add to skin damage that can lead to skin cancer. For this reason, skin specialists recommend that people use sunscreens that block both kinds of UV radiation.

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Resources
Information about skin cancer is available from the sources listed below. You may wish to check for additional information at your local library or bookstore and from support groups in your community.

Cancer Information Services (CIS)
The Cancer Information Services, a program of the National Cancer Institute, is a nationwide telephone service for cancer patients and their families and friends, the public, and health care professionals. The staff can answer questions (in English or Spanish) and can send free National Cancer Institute booklets about cancer. They also know about local resources and services. One toll-free number, 1-800-4-CANCER (1-800-422-6237), connects callers all over the country with the office that best serves their area.

American Cancer Society (ACS)
The American Cancer Society is a voluntary local offices all over the country. It supports research, conducts educational programs, and offers many services to patients and their families. To obtain information about services and local activities in local areas, call the Society's toll-free number, 1-800-ACS-2345 (1-800- 227-2345), or the number listed under "American Cancer Society" in the white pages of the telephone book.

Skin Cancer Foundation
Suite 2402
245 Fifth Avenue
New York, NY 10016
(212)725-5176
This nonprofit organization provides publications and audiovisual materials on prevention, early detection, and treatment of skin cancer. The Foundation also publishes Sun and Skin News and The Skin Cancer Foundation Journal, which have nontechnical articles on skin cancer. Send a stamped, self-addressed envelope to receive free printed information.

American Academy of Dermatology
Post Office Box 4014
Schaumburg, IL 60168-4014
(703)330-0230
The American Academy of Dermatology is an organization of doctors who specialize in diagnosing and treating skin problems. It provides free booklets on the center and can refer people to Dermatologist in their local area.

American Society of Plastic and Reconstructive Surgeons
444 East Algonquin Road
Arlington Heights, IL 60005
1-800-635-0635
This Society sends free information about various surgical procedures. It can also provide the names of board-certified plastic surgeons in a patient's area.
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For Further Information
The National Cancer Institute booklets listed below are available free of charge by calling 1-800-4-CANCER.
  • Facing Forward: A Guide For Cancer Survivors
  • Radiation Therapy and You: A Guide to Self-Help During Treatment
  • Taking Time: Support for People With Cancer and the People Who Care About Them
  • What Are Clinical Trials All About?
  • What You Need To Know About Melanoma
  • What You Need To Know About Moles and Dysplastic Nevi
  • When Cancer Recurs: Meeting the Challenge Again
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How To Do a Skin Self-Exam
You can improve your chances of finding skin cancer promptly by performing a simple skin self-exam regularly.

The best time to do this self-exam is after a shower or bath. You should check your skin in a well-lighted room using a full-length mirror and a hand held mirror. It's best to learn where your birth marks, moles, and blemishes are and what they usually look like. Check for anything new--a change in the size, texture, or color of a mole, or a sore that does not heal.

Check all areas, including the back, the scalp, between the buttocks, and the genital area.

  1. Look at the front and back of your body in the mirror, then raise your arms and look at the left and right side.
  2. Bend your elbows and look carefully at the palms, the forearms, including the undersides, and the upper arms.
  3. Examine the back and front of the legs. Also look between the buttocks and around the genital area.
  4. Sit and closely examine the feet, including the soles and the spaces between the toes.
  5. Look at your face, neck, and scalp. You may want to use a comb or a blow dryer to move hair so that you can see better.

Looking at BacksideExamine FeetLooking in Mirror
By checking your skin regularly, you will become familiar with what is normal. If you find anything unusual, see your doctor right away. Remember, the earlier skin cancer is found, the better the chance for cure.


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Topics
Illustrations by: Ray Simmons

Adapted from What You Need To Know About Skin Cancer a booklet written and published by the National Cancer Institute (NCI), 9000 Rockville Pike, Bethesda, MD 20892. The NCI is the U.S. Government's main agency for cancer research and information about cancer. The NCI's publications are free.

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